生物分子相互作用分析平台
- 多位点结合检测
- 结合表位筛选
- 多分子复合物检测
- 特异性分析
- 增强选择性检测
各种类型的相互作用分析
- 抗体-抗原,受体-配体相互作用表征:亲和力,动力学
- 化合物库的高通量筛选
- 针对靶蛋白的化合物/多肽的亲和力检测
- scFV或抗体的亲和力筛选与排序
- 多重结合顺序确认
- 抗体分型与交叉反应测试
Biacore 机型: Biacore 8K, Biacore T200, Biacore X100
ForteBio 机型: Octet RED 96
ka (1/Ms) | kd (1/s) | KD (M) |
4.788E+06 | 2.612E-04 | 5.455E-10 |
ka (1/Ms) | kd (1/s) | KD (M) |
3.539E+6 | 0.01163 | 3.287E-9 |
Protein-protein binding analysis using Biacore. The left figure is about binding of antigen to antibody. The right figure is about binding of a molecular chaperone GroEL to cochaperone GroES.
Fragment library screening service using Biacore T200 and 384-well plate. 350 fragments can be screened every day. This chart shows an example of screening of 3600 fragments. 41 hit were selected for further affinity characterization.