We are looking for a highly talented, self-motivated and experienced structural biologist to join our biologics discovery department. The successful candidate will be a project team leader, serving as liaison between the clients and ChemPartner; working closely with medicinal chemists from chemistry group or biologists from biologics discovery group. The candidate should have a proven track record on structural biology, able to work independently to solve co-crystal structures and determine antigen epitopes by x-ray crystallography or cryoEM. Additional responsibilities includes but not limited to lead and coordinate antibody engineering projects such as humanization, fragment based screening projects using SPR, NMR, MST and native-MS methods.
Desired skills and experience:
A PhD degree in structural biology, biophysics or related field.
Extensive hands-on experience in molecular cloning, protein expression and purification, protein crystallization screening, co-crystal preparation, structure determination and analysis.
With >3 years’ experience in synchrotron data collection and uses of structural determination software CCP4, COOT, PYMOL, PHENIX, XDS, and knowledge of SBDD and FBDD.
Hand-on experience on protein modeling and design tools such as Schrodinger, Discovery Studio, Rosetta, MOE, and/or experience on molecular dynamics and docking will be a PLUS.
Experience on protein-LMW compound/fragment interaction by SPR will be a PLUS.
Experience on Cryo-EM, and/or MicroED and/or HDX-MS, and/or LCP methods will be a PLUS.
Strong communication skills, both oral and written, in Chinese and English.
Ability to work in a fast-paced, team-oriented environment and demonstrate attention to details and record keeping
Lead a group of scientist on protein expression and purification for crystallization
Perform crystal screening and optimization, structural determination and analysis
Protein/Antibody Biophysical characterizations including SPR assay, thermal stability etc
Communicate with client and coordinate internal platforms for efficient project management
Strengthen and expand capabilities on structural biology, cryoEM, protein/ biophysical characterizations
Stay abreast of latest scientific and technology advancement in the field