Resource Category: 论文发表

REV-ERBα 选择性激动剂 SR-29065(34)用于自身免疫性疾病的结构-活性关系与生物学研究

Di Zhu, Qun Lu, Yuanjun He et al. J Med Chem. 2023 Nov 9;66(21):14815-14823. doi: 10.1021/acs.jmedchem.3c01413. Epub 2023 Oct 27.

抗人 APC 抗体在临床前模型中预防先天性凝血因子缺乏的安全性与有效性

Miao Jiang, Fubo Yang, Yajuan Jiang, Lihua Cheng, Jing Han, Jing Yi, Guangwei Zhang, Zhihua Ma, Liying Cao, Bin Zuo, Lixiang Zhou, Lihui Huang, Shuhua Niu, Zhiyong Xia, Xiaoping Zhou, Xiaohui Bai, Nancy L Esmon, Cangping Xia, Lihong Han, Cheng

开发高亲和力诱饵受体用于治疗多发性骨髓瘤与弥漫性大 B 细胞淋巴瘤

Yu Rebecca Miao et al. J Exp Med. 2022 Sep 5;219(9):e20220214. doi: 10.1084/jem.20220214. Epub 2022 Jul 26.

新型高亲和力嵌合 LAG-3 抗体 405B8H3(D-E) 的表征:具有强效抗肿瘤活性

Lan X, et al. FEBS Open Bio. 2023 Jul;13(7):1253-1265. doi: 10.1002/2211-5463.13648. Epub 2023 Jun 11.

新型人源 CD137 激动型抗体的开发与表征:具有抗肿瘤活性且在非人灵长类中安全性良好

Yingying Gao, Hongliang Li, Ning Su, Tianyi Yang, Chen Dong, Yanhong Dong. Development and characterization of a novel human CD137 agonistic antibody with anti-tumor activity and a good safety profile in non-human primates. FEBS Open Bio. 2022 Dec;12(12):2166-2178. doi: 10.1002/2211-5463.13494.

一种新型口服生物利用的小分子 PCSK9 抑制剂,在体内具有显著的降胆固醇作用

Suchowerska AK, Parmar J, Lambert G, Palmer JT, Treutlein H, Zeng J, Nativel B, Chemello K, Zhu Q, Wang J, Teng Y, Tang W, Xu Y, Rathi AK, Kumar S, Evison BJ. J Lipid Res. 2022 Nov;63(11):100293.

利用 H2L2 小鼠开发具有强效抗肿瘤活性的全人源抗 GITR 抗体

Tong Q, Yu T, Li H, Qian Q, Ding C. Development of a fully human anti-GITR antibody with potent antitumor activity using H2L2 mice. FEBS Open Bio. 2022 Aug;12(8):1542-1557. doi: 10.1002/2211-5463.13451. Epub 2022 Jun 21.

评估 STRAD 假激酶小分子变构调节剂的方法

Tingting Qing, John D Gordan. Methods Enzymol. 2022:667:427-453. doi: 10.1016/bs.mie.2022.03.041. Epub 2022 Apr 13.

Ivosidenib(一种用于治疗 IDH1 突变恶性肿瘤的突变型异柠檬酸脱氢酶 1 抑制剂)的临床前药物代谢、药代动力学与药效学特征

Chen Y, Nagaraja NV, Fan B, Uehling L, Linton RM, Perez-Moreno JP, Dutta L, Kim H, Song SS-M, Borthakur SA, Yang H, et al. Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1

中和 PD-L2 是克服卵巢癌免疫检查点阻断耐药的关键

Xu Y, Wei B, et al. Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer. Clin Cancer Res. 2021 Aug 1;27(15):4435-4448. doi: 10.1158/1078-0432.CCR-20-0482. Epub 2021 May 19.
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